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How does Apcalis work?

ED is a condition in which men fail to get or maintain an erection. A normal penile erection occurs when blood flows into the penis. Cyclic guanosine monophosphate (GMP) is a substance that relaxes the muscles in the organ and increases blood flow to cause an erection. In ED, this activity fails to work. Apcalis is a PDE5 inhibitor that works by blocking PDE5, and when PDE5 is blocked, the body makes more cGMP. The more cGMP you have, the more blood is flown to the penile organ. This allows blood to flow in the penile organ and produce an erection.

How long does it take for Apcalis to work?

Of all PDE5 inhibitors, Apcalis works relatively quickly to treat your ED symptoms. Research has shown that tadalafil may act as quickly as 30 minutes after taking the dose. However, in some users, the drug may take up 1 to 2 hours until they notice it is working. On average, Apcalis takes about 2 hours to peak. This is the longest duration of action of the drug. After 2 hours of dosage, Apcalis is fully into your system. Post-dosage, the drug remains in the body for up to 36 hours, which is not the case with other PDE5 inhibitors that work for up to 4 to 5 hours.

How to use Apcalis rightly?

Take Apcalis as needed, meaning when you intend to indulge in sexual activity. Keep in mind that you should not take the medicine more than once a day. The best time to take Apcalis 20 mg is about an hour before sexual intercourse because it takes that much time to offer its best effects. You can take the dose with or without food. You should not crush, split, or chew Apcalis pills. Swallow the pill whole. Do not consume alcohol, grapefruits, or cannabis (marijuana) while taking this ED medication. Do not overdose and more importantly, do not use it for recreational purposes.

What precautions do I need to take?

Apcalis comes with several precautions. Before taking the medicine, check with your doctor about your medical history. The medicine may not be right for you if you have medical conditions such as heart problems, pulmonary hypertension, blood pressure problems, stroke, liver problems, kidney dysfunction, vision loss, retinitis pigmentosa, stomach ulcers, bleeding problems, deformed penis (Peyronie’s disease), blood cell problems, or cancer. Apcalis is not advised to children, women, pregnant women, and breastfeeding mothers.

Which drugs interact with Apcalis?

Before taking Apcalis, talk with your doctor about all prescription or over-the-counter drugs you take. Also, tell about any multivitamins, herbs, or supplements you use. If you share this information, it can help avoid potential drug interactions. Apcalis adversely interacts with nitrates (nitroglycerin, isosorbide mononitrate, isosorbide dinitrate); alpha-blockers (tamsulosin, alfuzosin doxazosin); antihypertensive drugs (amlodipine, metoprolol, enalapril); guanylate cyclase stimulator (riociguat); protease inhibitor (ritonavir); certain antifungals and antibiotics.

What are the side effects of Apcalis?

Common side effects of Apcalis may include headache, flushing (warmth or redness), nausea, upset stomach, runny or stuffy nose, muscle pain, or back pain. Call your doctor immediately for medical assistance if any of these side effects persist. Stop sexual activity and get medical help if you have chest pain or dizziness. Get emergency medical attention if you experience signs of an allergic reaction such as rashes, difficulty breathing, or swelling of your face and lips, or if you experience chest pain or pressure, vision changes, and a prolonged, painful erection.

Does Apcalis work and is it safe?

The U.S. Food and Drug Administration (FDA) has approved tadalafil, the active ingredient of Apcalis, in 2003 for the treatment of erectile dysfunction. The FDA approves a drug only after the drug has been found safe and effective in human trials. In most men, Apcalis is a safe ED drug. However, for some, it may not be a safe option, such as those with heart conditions (irregular heart rhythm) and those who take nitrates or alpha-blockers. Before you start using this generic Cialis, make sure you follow all instructions carefully so you can use the drug safely and effectively.

The Bottom Line

Apcalis is recommended for the treatment of erectile dysfunction (ED). It is composed of an FDA-approved PDE5 inhibitor called tadalafil so it is nothing but a generic version of Cialis. It helps ED-affected men to regain their ability to attain or sustain an erection. Unlike other PDE5 inhibitors, Apcalis acts in your body for up to 36 hours, which is why it is called the weekend pill. It also has a shorter onset of action, meaning it works quickly. If you want to switch from Cialis to its generic version, Apcalis is probably the best choice of drug.